New York added a second run in the fourth on a wild throw by rookie catcher Adley Rutschman.
But still, New York shut down the struggling Orioles on Star Wars night at Yankee Stadium to win a second consecutive game following its first three-game slide of the year.
Sears worked around a leadoff walk and an error in the first inning, then pitched out of trouble again in the second.
“It was awesome.
Holmes, subbing for injured All-Star closer Aroldis Chapman, gave up two hits in the ninth before securing his fifth save.
Donaldson remained on the COVID-19 list, and All-Star infielder DJ LeMahieu sat out for the second consecutive night because of left wrist discomfort.
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